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Biochemical test shows promise for diagnosing Parkinson’s disease

Researchers have developed a biochemical test for diagnosing Parkinson’s disease (PD) using technology that detects misfolded α-synuclein (αSyn) oligomers in cerebrospinal fluid (CSF).

Their protein misfolding cyclic amplification (PMCA) platform technology takes advantage of the ability of minute misfolded oligomers, in this case αSyn, to nucleate further aggregation, enabling a very high amplification of the signal.

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